Hosomi-Sakurai反应（Sakurai烯丙基化反应）

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Hosomi-Sakurai反应是指烯丙基硅试剂与醛酮等羰基化合物的加成反应，可以用于合成高烯丙醇类化合物。一般需要加入路易斯酸来活化反应。




反应机理




反应实例





参考文献


1. Hosomi, A., Endo, M., Sakurai, H. Chem. Lett. 1976, 941-942.

2. Hosomi, A., Sakurai, H. Tetrahedron Lett. 1976, 1295-1298.

3. Trost, B. M., Thiel, O. R., Tsui, H.-C. J. Am. Chem. Soc. 2003, 125, 13155-13164.

4. Williams, D. R., Myers, B. J., Mi, L. Org. Lett. 2000, 2, 945-948.

5. Wender, P. A., Hegde, S. G., Hubbard, R. D., Zhang, L. J. Am. Chem. Soc. 2002, 124, 4956-4957.


摘自：有机人名反应——机理及应用 第四版，Strategic Applications of Named Reactions in Organic Synthesis


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