A solution of 50 mg (0.10 mmol) of 5-n-butyl-2-(5-carbomethoxy-2-chlorophenyl)-2,3-dihydro-4-(2-fluoro-4-bromobanzyl)-1,2,4-triazol-3-one in 1 ml of n-butylamine was stirred overnight at 65 "C. After being cooled to room temperature, volatiles were evaporated in vacuo. The residue was flash chromatographed (gradient elution with 1-5% MeOH in CH 2 C1 2 ) to yield 41 mg (76%) of a colorless, glassy solid.

      A 2M solution of trimethyl aluminium in hexane (1.9 mL) was added dropwise to a cold (0℃) solution of 4-amino-benzonitrile (0.29 g, 2.46 mmol) in anhydrous dichloromethane (30ml) under argon atmosphere. The mixture was warmed to room temperature and stirred at room temperature for 30 min. A solution of 4-methyl-3- (4- pyridin-4-yl-thiazol-2-ylamino)-benzoic acid methyl ester (0.80 g, 2.46 mmol) in anhydrous dichloromethane (30 mL) and added slowly, and the resulting mixture was heated at reflux for 5h. The mixture was cooled to 0.deg.C and quenched by dropwise addition of a 4N aqueous sodium hydroxide solution (3mL). The mixture was extracted with dichloromethane (3x20 mL). The combined organic layers were washed with brine (3x20 mL) and dried over anhydrous MgS04. N-(4-Cyano-phenyl)-4-methyl-3- (4- pyridin-4-yl-thiazol-2-ylamino)  benzamide is obtained in 98percent after trituration of the crude product in methanol.

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