将醛，酮等羰基的化合物和异丙醇铝在异丙醇中共热时，可还原得到相应的醇，同 时将异丙醇氧化为丙酮。这是仲醇用酮氧化反应的逆反应（Oppenauer 反应）。 

       异丙醇铝是脂肪族和芳香醛，酮类的选择性很高的还原剂，对分子中含有的烯键， 炔键，硝基，缩醛，腈基及卤素等可还原功能基无影响。 

反应机理及影响反应的因素 

      异丙醇铝还原羧基化合物时，首先是异丙醇铝的铝原子与羧基的氧原子以配位键结合，形成六元环过渡态，然后，异丙基上的氢原子以负离子的形式从烷氧基转移到羰基 碳原子上，得到一个新的醇-酮配合物，铝-氧键断裂，生成新的醇-铝衍生物和丙酮，蒸 出丙酮有利于反应完全。醇-铝衍生物经醇解后得到还原产物，本步是决定反应步骤， 因而反应中要求有过量的异丙醇存在。 

      本反应为可逆反应，因而，增大还原剂量及移出生成的丙酮，均可缩短反应时间， 使反应完全。由于新制异丙醇铝是以三聚体形式与酮配位，因此酮类与醇-铝的配比应 不少于 1：3，方可得到较高的收率。 

       反应中加入一定量的三氯化铝，使生成的一部分氯化异丙醇铝，可加速反应并提高收率。因为氯化异丙醇铝与羰基氧原子形成六元环的过渡态较快，使氢负离子转移较易。

     1，3-二酮，β-酮酯等易于烯醇化的羰基化合物，或含有酚性羟基等酸性基团的羰基化合物，其羟基易于与异丙醇铝形成铝盐，使还原反应受到抑制，因而，一般不采用本法还原。含有氨基的羰基化合物，也易与异丙醇铝形成复盐而影响还原反应进行，但 可改用异丙醇钠为还原剂 。 

 LiAlH(OPr-i)3还原酮示例 

    To dehydrated diethyl ether (12.6 ml) was added lithium aluminum tri-tert-butoxyhydride (457 mg), and the resulting mixture was cooled to -20.deg. C. followed by dropwise addition of a diethyl ether solution (5.3 ml) of (3R)-3-tert-butoxycarbonylamino-1-chloro-4-phenyl-2-butanone (500 mg).The resulting mixture was stirred at -20.deg. C. for 6 hours.To the reaction solution was added aqueous 5percent potassium hydrogen sulfate solution, to quench the reaction, which was then subjected to extraction twice in ethyl acetate; the organic layer was washed by aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate.After removal of magnesium sulfate, the resulting ethyl acetate solution was analyzed by HPLC. It was confirmed that the diastereomer mixture of 3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutazone was obtained in 90percent yield.The ratio of the objective (2S, 3R) compound and the isomer (2R, 3R) was (2S, 3R): (2R, 3R)=76.9:23.1. The solvent was evaporated from the resulting solution under reduced pressure, to afford crude (2S, 3R)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane (0.502 g) in solid 。

 LiAlH(OBu-t)3还原酮示例 

    3β-Acetoxy-20β-hydroxy-5-pregnene. In a 2-l. five-necked flask fitted with a mechanical stirrer, 250-ml. dropping funnel, thermometer, nitrogen-inlet tube, and reflux condenser with calcium chloride tube is placed 750 ml. of anhydrous tetrahydrofuran. The vessel is flushed with nitrogen, and 101.6 g. (0.4 mole) of lithium aluminum tri-t-butoxyhydride is added. The suspension is cooled to about 2℃, and 71.7 g. (0.2 mole) of pregnenolone acetate  is added in one portion while stirring, the particles adhering to the wall of the flask being rinsed into the solution with an additional 50 ml. of tetrahydrofuran. The reaction mixture is stirred at 0–5℃for 6 hours. A solution of 100 g. of ammonium sulfate in 150 ml. of water is added, with stirring, over a 15–20 minute period through the dropping funnel, the temperature of the reaction mixture being kept below 10℃ by efficient cooling with ice. A considerable quantity of hydrogen is evolved. There is added 20 g. of filter aid (Celite® or Hyflo Supercel®), the mixture is stirred for another 30 minutes, and it is finally filtered with suction through a layer of filter aid. The reaction vessel is rinsed and the filter residue thoroughly washed with 1.5 l. of tetrahydrofuran. The filtrate is evaporated to dryness under reduced pressure. The crystalline residue is dissolved in 750 ml. of hot acetone, filtered (if necessary), and the solution is concentrated to a volume of about 200 ml. (crystallization may begin during this evaporation). The flask is kept overnight at 0℃ to −10℃ and the product isolated by suction filtration. The crystals are washed with 75 ml. of ice-cold acetone and dried at 60°. The yield of the product is 54–57 g. (75–79%), m.p. 161–164℃. [α]25D −74° (c 1.0, CHCl3).